Hormone Clomid Anti Estrogen Steroids Pharmatical CAS 50-41-9 Clomiphene Citrate Pills

Hormone Clomid Anti Estrogen Steroids Pharmatical CAS: 50-41-9 Steroids Pill

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Clomid Basic Info

Name: Clomiphene Citrate
Alias:Clomid, Serophene, Clomphid, Pergotime
CAS No.: 50-41-9
MF: C32H36ClNO8
MW: 598.08
Purity: 99.57%
Appearance: White Crystalline Powder
Place of Origin: China
Standard: USP32
Certification: SGS
Method of Analysis: HPLC

Clomid Description:
 

Clomid is a generic name for Clomiphene Citrate and is a synthetic oestrogen.

Most anabolic steroids, especially the androgens, cause inhibition of the body's own testosterone production. When a bodybuilder comes off a steroid cycle, natural testosterone production is zero and the levels of the steroids taken in the blood are diminishing. This leaves the ratios of catabolic : anabolic hormones in the blood high, hence the body is in a state of catabolism, and, as a result, much of the muscle tissue that was gained on the cycle is now going to be lost.

Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.

Clomid Application:
 

Clomid works as an anti-oestrogen. As it's a weak synthetic oestrogen, it binds to oestrogen receptors on cells blocking them to oestrogen in the blood. This minimises the negative effects like gynecomastia and water retention that may be a result of oestrogen that has aromatised from testosterone.

Clomifene Citrate has also been used with other assisted reproductive technology to increase success rates of these other modalities.

As for toxicity and side effects, Clomifene Citrate is considered a very safe drug. Bodybuilders seldom report any problems, but listed possible side effects do include hot flashes, nausea, dizziness, headaches and temporarily blurred vision.

Such side effects usually only appear in females however, as they feel the effects of estrogen manipulation much more readily than men. While female athletes can clearly gain some benefit from this substance, estrogen manipulation is probably not the most comfortable way to go about cutting up.

Should it still be used for such purposed and side effects do become pronounced, the drug of course is to be discontinued and (at least) a break taken from it.

Clomid During A Cycle:
 

When we use anabolic steroids, the level of androgens in the body rises causing the androgen receptors to become more highly activated, and through the HPTA, a signal tells our testes to stop producing testosterone. During a cycle the body has far higher than normal levels of androgens and, as long as this level is high enough, Clomid will not help to keep natural testosterone production up. It will be almost all but completely shut off, in theory.

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