10mg * 10vials Sex Hormones , High Purity PT 141 Peptide CAS 32780-32-8

Sex Enhence Protein Peptide Hormones PT141 Bremelanotide 10mg*10vials for Sexual Disorders

Basic infor:
 

PT-141 Cas No. :32780-32-8
PT-141 M.F. :C50H68N14O10
PT-141 M.W :1025.2
PT-141 Purity (HPLC):98.0%min.
PT-141 Appearance: White powder
PT-141 Single Impurity (HPLC): 1.0%max
PT-141 Amino Acid Composition: ±10% of theoretical
PT-141 Peptide Content (N%):≥80.0%

PT-141 Water Content(Karl Fischer):≤6.0%
PT-141 Acetate Content (HPIC): ≤15.0%
PT-141 MS(ESI):Consistent
PT-141 Mass Balance: 95.0~105.0%

Description:

PT-141 (Bremelanotide) is a highly potent synthetic peptide analogue of α-MSH that may elicit aphrodisiac effects through stimulation of melanocortin receptors. PT-141 (Bremelanotide) consists of seven amino acids and is a cyclic, shortened lactam variant of alpha-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of physiological functions. In studies, bremelanotide was shown to induce lordosis in an animal model and was also effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).

Usage:

Bremelanotide, similarly to its analogues α-MSH and melanotan II, acts as a non-selective agonist of all of the melanocortin receptors except MC2, where it lacks significant affinity. Reported activity of the drug is as follows:
MC1 (Ki = 0.68 nM)
MC2 (Ki > 1000 nM)
MC3 (Ki = 72.07 nM)
MC4 (Ki = 19.25 nM)
MC5 (Ki = 166.8 nM)
Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors.
According to Palatin Technologies' original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than melanotan II.

Function:

1. Bremelanotide or PT-141 is use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder).

2. The mechanism of action of PT-141 may offer significant safety and efficacy benefits over currently available products because it acts on the pathway that controls sexual function without acting directly on the vascular system.

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