Acadesine SARM Steroids 99 . 7% Purity Pharmaceutical Grade For Fat Burning

99.7% Pure SARM Steroids AICAR/Acadesine Pharma Grade Powder and Pills for Fat Burning Effective

Product details:

Product description
Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Function:
 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

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1, We only send the HIGHEST purity Steroids, Peptides, Research chemicals & Pharmaceuticals which are very popular in many countries like Kazakhstan ,Poland,Hungary ,Paraguay ,Uruguay,Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium,Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Serbia,Finland ,Italy , Estonia ,Thailand, Israel ,US, UK, Canada, Australia
2, Our prices are the best because of the discounts that we give to all our buyers. We give very good discounts which makes our prices outstanding in the market.
3, Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online. We have adequate stock, and can arrange the delivery within 24hours when receiving the payment. Tracking number would be informed quickly after shipment.
4, We have the best customer service and excellent shipment ability. Contact us to have a full list of our products and price list.
5, Besides raw steroid powder and liquid,we offer hormone solution and formula.We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.

How to Proceed Your Orders?

Step 1
Please let me know the items you are favorable, quantities, and the destination country.
Step 2
You confirm all details, and offer us purchasing order.
Step 3
We send the detail price of our product and offer the suitable shipping method for reference.
Step 4
You confirm the order and pay money 100% in advance and send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements.
Step 5
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1 day later.
If send by HKEMS or other express,the tracking number would be provided next day. And this does not mean the info is trackable that day. It would be released on internet 2 or 3 days later . The reason why is that parcel should be shipped to Hongkong from forwarder then wait for the flight.
You sign for the parcel , deliveried.
Step 6
We offer after-sales service after you receive parcel.